. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Circulation. 2019 May 21;139(21):e997–e1012. doi: 10.1161/CIR.0000000000000679

Table 1.

Studies of Exercise on Clinical and CVD Outcomes in Patients With Cancer in the Adjuvant and Postadjuvant Setting

Setting	Clinical Outcomes	Cardiovascular Outcomes
Adjuvant
Breast	↓ CVD events²²	↑²³ ↔²⁴ ↓²⁵ CRF
	↓ CAD mortality²²	↓ LVEF²⁶
Prostate		↑ CRF²⁷
Colorectal		↑ CRF
Mixed (meta-analysis)		↑ CRF²¹
Postadjuvant
Breast	↓ CVD events²⁸	↔ ↑ CRF
	↓ All-cause mortality²⁹	↑ Vascular function
Prostate		↑ CRF³⁰
		↑ Vascular function³⁰
		↔ Lipid profile³⁰
		↔ Blood pressure³⁰
ASCC	↓ CVD events³¹
	↓ All-cause mortality³¹
Testicular		↑ CRF³²
		↑ Vascular function³²
		↑ Framingham Risk Score³²
Colorectal	↓ All-cause mortality²⁹	↑³³ ↔³⁴ CRF
Leukemia		↑ CRF³⁵
Lymphoma		↑ CRF³⁶
Mixed (meta-analysis)		↑ CRF²¹

Downward-pointing arrow (↓) indicates a decrease; upward-pointing arrow (↑) indicates an increase; and sideways-pointing arrow (↔) indicates no change. ASCC indicates adult survivors of childhood cancer; CAD, coronary artery disease; CRF, cardiorespiratory fitness; CVD, cardiovascular disease; and LVEF, left ventricle ejection fraction.