. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Circulation. 2019 May 21;139(21):e997–e1012. doi: 10.1161/CIR.0000000000000679

Table 2.

Feasibility and Outcomes of Exercise Training in CR Model for Patients With Cancer

Author	Sample Size, n	Cancer Type	Stage	Timing	Supervision	Exercise Prescription	Length	Physiological Outcomes	PROs	Adherence, %
Dittus et al³⁸	280	68% Breast, 32% other	NA	2.4±3.7 y from diagnosis	Supervised by exercise specialist; group setting in CR	2 times/wk supervised Aerobic: 20 mins 3–4 times/wk 70%–85% PHR progressing to 40 mins 4–5 times/wk Resistance: 60%–70% 1-RM U/L extremity	12 wk	↑ 6-min walk ↑ U/L extremity strength	↑	74
Young-McCaughan et al³⁹	62	22% Breast, 19% prostate, 59% other	Stage 0 or 1=30% Stage 2=39% Stage 3 or 4=29%	During treatment: 24% Completed therapy: <6 mo, 37%; >6 mo, 39%	Supervised by exercise specialist; group setting in CR	2 times/wk supervised exercise Aerobic: walking 3–5 times/wk Resistance: none	12 wk	↑ METs	↑	40–85, varied by stage and treatment
Dolan et al⁴⁰	152	Breast cancer survivors	Early stage	177±167 wk from surgery	Supervised by exercise specialist; group setting in CR	1 time/wk supervised Aerobic: 4 times/wk walking 1–3 miles 60–80% VO₂ reserve Resistance: 2 times/wk	22 wk	↑ VO₂peak	↑	67
Hubbard et al⁴¹	41	Colorectal cancer survivors	NA	Recovery period after surgery	Supervised by exercise specialist; group setting in CR	1–2 times/wk supervised Aerobic: 50 min based on Borg RPE Resistance: 25 min/bout	6–12 wk	Feasibility	Feasibility	62
Hsieh et al⁴²	96	Breast cancer survivors	NA	Immediately after surgery alone (n=22), after surgery+chemotherapy (n=30), after surgery+radiation (n=17), after surgery+chemotherapy+radiation (n=27)	Individually supervised by exercise specialist in oncology rehabilitation setting based on CR	2–3 times/wk supervised Aerobic: 40 mins 40%–70% PHR Resistance and stretching: 20 min	6 mo	↑ VO₂max and time on treadmill (P<0.05) for all groups	↑ For all groups	90
De Jesus et al⁴³	20	Breast cancer scoring high on fatigue scale	1–3	Within 4 mo of adjuvant therapy	Supervised by exercise specialist in group setting, CR administered at YMCA (community based)	3 times/wk supervised Aerobic: 50%–70% VO₂max; 15 min progressing 45 min/bout Resistance: none	16 wk	Feasibility	Feasibility	30

CR indicates cardiac rehabilitation; MET, metabolic equivalent; NA, not available; PHR, peak heart rate; PRO, patient-reported outcomes; RM, resistance maximum; RPE, rating of perceived exertion; and U/L, upper/lower.