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. 2020 Sep 10;8(5):390–398. doi: 10.1093/gastro/goaa049

Figure 3.

Figure 3.

PD-L1 promotes EMT by activating PI3K/AKT signaling. (A) Western-blot assay of Sterol regulatory element-binding protein 1 (SREBP-1) in LV-PD-L1-WT-HepG2 SR and LV-PD-L1-WT-Huh7 SR cells following overexpression of PD-L1. (B) Western-blot assay of SREBP-1 in LV-PD-L1-shRNA-HepG2 SR and LV-PD-L1-shRNA-Huh7 SR cells following knock-down of PD-L1. (C) p-AKT and E-cadherin levels in LV-PD-L1-WT-HepG2 SR cells overexpressing PD-L1 and Huh7 SR cells following knock-down of SREBP-1. β-actin was used as an endogenous control.