Table 4.
HCoV spike protein-receptor interactions (≤4.5 Å).
| PDB:3SCI |
| SARS-CoV: K390, R426, Y436, Y440, F442, L443, P462, D463, F472, N473, Y475, N479, Y481, G482, Y484, T486, T487, G488, I489, Y491 |
| hACE-2: S19, Q24, T27, F28, D30, K31, H34, E37, D38, Y41, Q42, L45, M82, Y83, Q325, E329, N330, K353, G354, D355, R357, R393 |
| Hydrogen bonds between SARS-CoV and hACE-2: T486-Y41, Y484-Q42, R426-E329, Y436-D38, G488-K353 |
| PDB:6LZG |
| SARS-CoV-2: K417, G446, Y449, Y453, L455, F456, Y473, A475, G476, E484, F486, N487, Y489, F490, Q493, G496, Q498, T500, N501, G502, Y505 |
| hACE-2: S19, Q24, T27, F28, D30, K31, H34, E35, E37, D38, Y41, Q42, L45, L79, M82, Y83, N330, K353, G354, D355, R357, R393 |
| Hydrogen bonds between SARS-CoV-2 and hACE-2: A475-S19, N487-Q24, T500-Y41, K417-D30, Y449-D38, Y449-Q42, N487–Y83, Q498-Q42, T500-Y41, N501–Y41, G502-K353 |
| PDB:6Q04 |
| MERS-CoV: Q36, F39, H91, A92, F101, I132, S133, P134, S135, Q304, R307 |
| Hydrogen bonds between MERS-CoV with sialic acid: A92-O9, R307-O8, R307-O9, I132–N5, A92-O9 |
| PDB:4L72 |
| MERS-CoV: S454, D455, P463, Y499, N501, K502, S504, L506, D510, R511, E513, P515, E536, D537, G538, D539, Y540, R542, W553, V555, A556, S557, S559 |
| hDPP4: T188, T265, K267, F269, Q286, T288, A289, P290, A291, S292, L294, I295, G296, H298, R317, Y322, S333, S334, R336, V341, Q344, I346, K392 |
| Hydrogen bonds between MERS-CoV and hDPP4: D359-K267, E513-A291, D510-Y322, Y499-R336, E513-Q344 |
| PDB:6NZK |
| HCoV-OC43: N27, K29, T31, L80, K81, G82, S83, L85, L86, S87, W90 |
| Hydrogen bonds between HCoV-OC43 with sialic acid: N27-OA9, S83–O3, K81–N5 |
| PDB:3KBH |
| HCoV-NL63: G494, G495, S496, C497, Y498, V499, C500, H503, G534, S535, P536, G537, S539, S540, W585, H586 |
| hACE-2: D30, N33, H34, E37, Y41, P321, N322, M323, T324, Q325, G326, N330, K353, G354, D355, F356, R357, M383, A386, A387, R393 |
| Hydrogen bonds between HCoV-NL63 and hACE-2: S540-T324, Y498-E37, S535–K353, S540-T324 |
| PDB:6ATK |
| HCoV-229E: S312, G313, G314, G315, K316, C317, F318, N319, C320, R359, W404, S407, K408 |
| hAPN: T244, E286, F287, D288, Y289, V290, E291, K292, W303, I309, A310, D315, L318 |
| Hydrogen bonds between HCoV-229E and hAPN: N319-E291, G314-D288, G315-F287, G315-D288, F318–Y289, N319-E291, K408-E291 |