Table 1.

Diagnostic criteria for multisystem inflammatory syndrome in children and Kawasaki disease

Diagnostic criteria for multisystem inflammatory syndrome in children4

1. Age <21 years

2. Fever (documented ≥38.0°C ≥24 hours or subjective fever ≥24 hours)

3. Laboratory evidence of inflammation (elevated erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], fibrinogen, procalcitonin, D-dimer, ferritin, lactic acid dehydrogenase [LDH],

interleukin 6 [IL-6], neutrophilia, lymphocytopenia, hypoalbuminemia)

4. Multisystem involvement (≥2 organ systems)

5. Severe illness requiring hospitalization

6. No alternative plausible diagnoses

7. Recent or current SARS-CoV-2 infection (as confirmed by RT-PCR, serology, or antigen test) or exposure within 4 weeks before onset of clinical manifestations

Diagnostic criteria for Kawasaki disease56

Fever for ≥5 days plus ≥4 of the following features:

1. Bilateral bulbar conjunctival injection

2. Oral mucositis (erythematous or fissured lips, injected pharynx, or strawberry tongue)

3. Extremity changes (erythema of palms or soles, edema of hands or feet, periungual desquamation)

4. Polymorphous rash

5. Cervical lymphadenopathy