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Percentage fraction of 4-O-methylhonokiol, MHNK remaining (blue) and converted to honokiol, HNK (green) in C57BL/6 mouse intestinal S9 fraction (a), liver S9 fraction (b) and liver microsomes (c) at 0.02 mg/mL final protein concentration and three MHNK concentrations (5, 1 and 0.5 μM) in the phase I CYP metabolism reaction mixture (200 µL) incubated at 37oC for 60 mins. Each experiment was run in triplicates and results were presented as mean ± SD.
