Table 3.
Pharmacokinetic Parameters of MGN, HNK, MHNK and Their Respective Metabolites (Glucuronides and Sulfates) After Oral Administration With 60 mg ME/kg dose in Corn Oil (n = 5)
| Parameters | Tmax (hr) | Cmax (ng/mL) | AUC0–24 (hr*ng/mL) | AUC0−∞ (hr*ng/mL) | Half-life (hr) | MRT0–24 (hr) |
|---|---|---|---|---|---|---|
| MGN | 0.9 ± 0.7 | 9.4 ± 3.3 | 23.1 ± 5.3 | 37.8 ± 16.5 | 3.8 ± 2.3 | 2.3 ± 0.6 |
| MGN_Glucuronide | 0.9 ± 0.7 | 697.5 ± 79.0 | 1830.5 ± 352.4 | 2320.1 ± 959.5 | 4.6 ± 3.0 | 3.0 ± 0.6 |
| MGN_Sulfate | 0.6 ± 0.3 | 477.7 ± 169.5 | 789.3 ± 195.2 | 1039.3 ± 223.3 | 4.5 ± 2.2 | 2.3 ± 0.4 |
| HNK | 1.0 ± 0.7 | 9.3 ± 3.8 | 26.4 ± 6.7 | 41.5 ± 17.8 | 4.2 ± 2.1 | 2.7 ± 0.5 |
| HNK_Glucuronide1 | 0.6 ± 0.3 | 80.4 ± 12.6 | 302.4 ± 90.8 | 338.6 ± 78.5 | 3.6 ± 1.4 | 4.0 ± 1.0 |
| HNK_Glucuronide2 | 0.5 ± 0.3 | 368.9 ± 69.4 | 1242.8 ± 359.5 | 1268.3 ± 347.4 | 4.5 ± 2.2 | 4.8 ± 0.5 |
| HNK_Sulfate | 0.6 ± 0.3 | 113.5 ± 36.2 | 192.8 ± 64.8 | 260.8 ± 60.7 | 4.6 ± 1.3 | 2.6 ± 0.6 |
| MHNK | 1.3 ± 0.6 | 3.7 ± 0.9 | 9.6 ± 4.0 | 10.8 ± 3.0 | 1.4 ± 0.6 | 1.8 ± 0.3 |
| MHNK_Glucuronide | 1.0 ± 0.6 | 30.9 ± 8.1 | 96.4 ± 30.8 | 107.4 ± 44.9 | 2.3 ± 1.9 | 2.7 ± 0.4 |
| MHNK_Sulfate | - | - | - | - | - | - |