Table 3.

Systemic organ involvement in children with COVID-19 and MIS-C

Cardiac	Raised troponin/BNP Myocarditis/pericarditis Valvulitis Pericardial effusion Coronary artery dilation/aneurysm Shock (requiring inotropic support)
Respiratory	Pneumonia ARDS Pleural effusion
Gastrointestinal	Diarrhea ± vomiting Abdominal pain Transaminitis Ascites Hepatosplenomegaly Colitis/ileitis
Dermatologic	Kawasaki-like eruption
Neurologic	Encephalopathy Seizures Stroke Brain imaging sequelae
Ophthalmologic	Conjunctival injection Nonsuppurative/nonpurulent conjunctivitis
Renal	Acute kidney injury Proteinuria ± hematuria
Hematologic	Coagulopathy (including thrombosis) Leukocytosis Raised inflammatory markers (eg, ferritin)

ARDS, acute respiratory distress syndrome; BNP, brain natriuretic peptide; MIS-C, multisystem inflammatory syndrome in children.