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. 2020 Oct 28;12:10669–10678. doi: 10.2147/CMAR.S266421

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© 2020 Liu et al.

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LATS2 acts as a target of miR-15b-5b and negatively regulated by miR-15b-5p. (A) miRanda was used to predict miR-15b-5b targeted to WT or Mut 3′-UTR of LATS2. (B) After miR-15b-5b overexpression, luciferase activity assay was performed to detect the luciferase activity of reporters containing WT or Mut 3ʹ-UTR of LATS2 with miR‐15b‐5p target sites in RWPE-1 cells. (C) The same method was used to detect the luciferase activity in prostate cancer PC-3 cells. Comparisons were performed using the paired t-test. ****p <0.0001. NS indicates no significant difference. Error bars represent SEM. Data represent three independent experiments.