Table 3.
Differences between bone marrow-derived mesenchymal stromal cells and placenta-derived decidual stromal cells.
| Characteristic | MSC | DSC |
|---|---|---|
| Expansion potential | ++ | ++++ |
| Differentiation to fat and cartilage | +++ | +/– |
| Size, volume | 4600 fl | 2400 fl |
| Express PDL-1, PDL-2 | + | ++ |
| Express CD49d, homing to inflammatory tissue (integrin) | + | ++ |
| Vascular cell adhesion molecule 1 (VCAM-1) expression | + | – |
| Express HLA class II after IFNγ stimulation | + | – |
| Pro-coagulant tissue factor | 6% | 39% |
| CD55 complement regulatory activity | 62% | 98% |
| Reduction in clotting time | 55% | 70% |
| Prevent alloreactivity in vitro (MLC) | ++ | +++ |
| Needs direct contact for immunosuppression | – | + |
| Overall response in steroid refractory acute GVHD | 75% | 100% |
MLC, mixed lymphocyte culture.