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. 2020 Oct 19;11:570903. doi: 10.3389/fmicb.2020.570903

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Copyright © 2020 Hu, He, Elsheikha, Zou, Ehsan, Ma, Zhu and Cong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional analysis of the differentially expressed transcripts (DETs). (A) The top 10 Gene Ontology (GO) terms and KEGG pathways of the DETs detected in the brain of acutely- and chronically-infected mice are shown. (B) Circos plot showing the relationship between GO terms and the corresponding genes. A number of genes related to immune response were enriched for biological process such as response to interferon-beta and interferon-gamma, T-cell activation, and positive regulation of cytokine production.