Table 3.
Neddylation in CLDs.
| CLD | Substrate | CRL/E3 ligase | Function | Reference |
|---|---|---|---|---|
| Hepatitis B | SMC5/6 | CRL4HBx/HDM2 | Promotes HBV replication | (77, 78) |
| NAFLD/NASH | ETFs | ? | Promotes hepatic steatosis | (82) |
| SRSF | ? | (83) | ||
| SREBP1c | HDM2 | (84) | ||
| NRF2 | CRL3 | (85) | ||
| Liver fibrosis | c-Jun | CRL? | Promotes activation of HSC and inflammation | (91) |
| IkBα | CRL1β−Trcp | (93) | ||
| TGFb-RII | c-CBL | (56) | ||
| HCC | HuR | Mdm2 | Promotes proliferation, survival and metastasis of cancer cells | (54, 99) |
| SREBP1 | ? | Regulates pro-tumorigenic | (68) | |
| LKB1 | ? | inflammation Regulates the function of immune cells | (100) | |
| Akt | ? | (100) | ||
| HIF1a | CRL2VHL | (106–109) | ||
| HIF2a | ? | (110) | ||
| Bax/SARM | SAG | (112) |