. 2020 Nov;375(2):385–396. doi: 10.1124/jpet.120.000191

TABLE 2.

PN/PNL ratios as determined by Orthogonal Regression in each tissue^a

Tissue	Parameters ^b(RSE%)
Tissue	PN_max (ng/ml)	PNL₅₀ (ng/ml)	f_m
Fat	166 (41.9)	283 (202)
Bone	108 (28.4)	314 (173)
Spleen	230 (48.2)	794 (252)
Heart	338 (63.3)	2575 (251)
Intestine	589 (62.8)	3174 (231)
Plasma	249 (47.2)	1276 (224)
Kidney			0.076 (39.5)
Lung			0.016 (7.7)
Brain			0.059 (26.7)
Skin			0.064 (17.2)
Muscle			0.060 (28.3)

^{^a}

f_m, linear PN/PNL ratio estimated according to eq. 35; PN_max and PNL₅₀, the maximal PN conc. achievable and the PNL conc. at which half of the maximal PN conc. is achieved estimated based on eq. 36.