TABLE 4.

Summary of prednisolone tissue partition coefficients by several methods

Tissue	PBPK	Infusiona	Method 1	Method 2	Method 3
Kp,Lung	1.00	1.21 ± 0.47	0.86	0.7	0.53
Kp,Brain	0.05	0.03 ± 0.003	1.24	0.89	0.63
Kp,Kidney	1.02	0.22 ± 0.05	0.79	0.66	0.47
Kp,Kidney (uncorrected)	0.79	0.17 ± 0.04
Kp,Heart	1.17	0.92 ± 0.19	0.74	0.64	0.47
Kp,Intestine	1.17	1.37 ± 0.78	NAb	NAb	NAb
Kp,Spleen	1.01	0.47 ± 0.16	0.67	0.64	0.46
Kp,Muscle	1.88	0.32 ± 0.02	0.67	0.6	0.36
Kp,Liver	1.31	3.67 ± 0.19	0.77	0.63	0.48
Kp,Liver (uncorrected)	0.58	1.63 ± 0.08
Kp,Skin	1.01	0.57 ± 0.30	0.81	0.63	0.46
Kp,Bone	0.22	0.29 ± 0.13	NAc	NAc	NAc
Kp,Fat	0.17	0.14 ± 0.05	0.51	0.4	0.42
Kp,Remainder	1.00 (Fixed)

NA, not applicable.

^aCalculated based on SS infusion study with n = 2 (S.D. provided).

^bTissues associated with gastro-intestinal tract were lumped together.

^cDifferent bone marrows were listed separately in software.