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. 2020 Oct 19;8:579943. doi: 10.3389/fcell.2020.579943

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Copyright © 2020 Kaveh, Bruton, Buckley, Oremek, Tucker, Mullins, Taylor, Rossi and Denvir.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of the larval zebrafish immune response to heart injury. Following laser heart injury in the early phase (0–2 hpi), immune cells resident to nearby pericardial tissues are recruited to the ventricle. At the same time, distal neutrophils and macrophages begin to egress from the CHT into the vascular system. Distal macrophages and neutrophils subsequently utilize blood and lymphatic vessels to migrate to the injured heart, joining locally recruited immune cells during the peak phase (6–24 hpi). The majority of these cells actively crawl along the abluminal surface of vessels, but some also roll and flow along the inside of vessels. The resolution phase is characterized by reverse migration of immune cells to adjacent tissues (> 6 hpi). Created with Biorender.com.