Table 1.
Information on the 23-IRGP.
| Gene Pair1 | Full Name | Immune Processes | Gene Pair2 | Full Name | Immune Processes | Coefficient |
|---|---|---|---|---|---|---|
| CD8A | CD8a molecule | Antigen_Processing_and_Presentation, Antimicrobials, TCRsignalingPathway | LTBP2 | latent transforming growth factor beta binding protein 2 | Cytokines | −0.009639653 |
| HSPA1A | heat shock 70kDa protein 1A | Antigen_Processing_and_Presentation | LYZ | lysozyme (renal amyloidosis) | Antimicrobials | 0.098898359 |
| HSPA1A | heat shock 70kDa protein 1A | Antigen_Processing_and_Presentation | GBP2 | guanylate binding protein 2, interferon-inducible | Antimicrobials | 0.06573857 |
| HSPA1A | heat shock 70kDa protein 1A | Antigen_Processing_and_Presentation | LTBP3 | latent transforming growth factor beta binding protein 3 | Cytokines | 0.00106882 |
| ICAM1 | intercellular adhesion molecule 1 | Antigen_Processing_and_Presentation, NaturalKiller_Cell_Cytotoxicity | PLXNB2 | plexin B2 | Chemokine_Receptors, Cytokine_Receptors | -0.039340917 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | Antigen_Processing_and_Presentation | NENF | neuron derived neurotrophic factor | Cytokines | −0.008677831 |
| ZC3HAV1L | zinc finger CCCH-type, antiviral 1-like | Antimicrobials | CMTM8 | CKLF-like MARVEL transmembrane domain containing 8 | Cytokines | 0.037052249 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Antimicrobials | IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | Antimicrobials | -0.511310011 |
| CYBB | cytochrome b-245, beta polypeptide | Antimicrobials | SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | Chemokines, Cytokines | −0.0389128 |
| TRIM5 | tripartite motif-containing 5 | Antimicrobials | SOS1 | son of sevenless homolog 1 (Drosophila) | NaturalKiller_Cell_Cytotoxicity, TCRsignalingPathway | −0.064111635 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | Antimicrobials, Cytokines, NaturalKiller_Cell_Cytotoxicity, TNF_Family_Members | STC1 | stanniocalcin 1 | Cytokines | −0.089600117 |
| RNASEL | ribonuclease L (2’,5’-oligoisoadenylate synthetase-dependent) | Antimicrobials | TRIM22 | tripartite motif-containing 22 | Antimicrobials | 0.019575179 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | Antimicrobials | DDX17 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | Antimicrobials | −0.036983795 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | Antimicrobials, Cytokine_Receptors | BIRC5 | baculoviral IAP repeat-containing 5 | Antimicrobials | −0.008823763 |
| ISG15 | ISG15 ubiquitin-like modifier | Antimicrobials | NENF | neuron derived neurotrophic factor | Cytokines | −0.225283963 |
| GNLY | granulysin | Antimicrobials | EDNRA | endothelin receptor type A | Chemokine_Receptors, Cytokine_Receptors | −0.027334821 |
| IRF7 | interferon regulatory factor 7 | Antimicrobials | AKT1 | v-akt murine thymoma viral oncogene homolog 1 | BCRSignalingPathway, TCRsignalingPathway | −0.035142572 |
| TRIM22 | tripartite motif-containing 22 | Antimicrobials | CCL17 | chemokine (C-C motif) ligand 17 | Antimicrobials, Chemokines, Cytokines | −0.270054236 |
| BIRC5 | baculoviral IAP repeat-containing 5 | Antimicrobials | NGFR | nerve growth factor receptor (TNFR superfamily, member 16) | Cytokine_Receptors | 0.211653036 |
| GBP2 | guanylate binding protein 2, interferon-inducible | Antimicrobials | PLXNA1 | plexin A1 | Chemokine_Receptors, Cytokine_Receptors | −0.031264198 |
| GBP2 | guanylate binding protein 2, interferon-inducible | Antimicrobials | SHC4 | SHC (Src homology 2 domain containing) family, member 4 | NaturalKiller_Cell_Cytotoxicity | −0.09011139 |
| PTK2B | PTK2B protein tyrosine kinase 2 beta | Antimicrobials, NaturalKiller_Cell_Cytotoxicity | LHB | luteinizing hormone beta polypeptide | Cytokines | −0.397220258 |
| CD86 | CD86 molecule | Antimicrobials | IL1RN | interleukin 1 receptor antagonist | Cytokines, Interleukins | −0.018374851 |