Table 2.

Univariate Cox and Multivariate Cox analysis of clinicopathological factors and risk signatures.

Variable	Univariate Cox analysis of clinicopathologicalfactors and risk signatures			Multivariate Cox analysis of clinicopathologicalfactors and risk signatures
TCGA-train dataset
id	HR	95% CI	p-value	HR	95% CI	p-value
age	1.02	1.00–1.04	0.013	1.01	0.99–1.03	0.221
gender	1.11	0.73–1.49	0.621	1.25	0.79–1.71	0.339
stage	1.54	1.20–1.88	0.001	1.56	1.20–1.92	0.001
riskScore	10.41	6.43–14.39	1.49E-21	10.64	6.47–14.81	1.15E-20
TCGA-test dataset
id	HR	95% CI	p-value	HR	95% CI	p-value
age	1.02	1.01–1.03	0.002	1.02	1.01–1.03	0.002
gender	0.94	0.60–1.28	0.805	0.84	0.53–1.15	0.469
stage	1.27	1.02–1.52	0.036	1.3	1.03–1.57	0.029
riskScore	2.12	1.44–2.80	0	2.08	1.41–2.75	0.0002
TCGA dataset
id	HR	95% CI	p-value	HR	95% CI	p-value
age	1.02	1.01–1.03	0.011	1.01	0.98–1.04	0.010
gender	1.04	0.60–1.48	0.701	1.02	0.61–1.43	0.412
stage	1.42	1.31–1.63	0.006	1.13	0.83–1.43	0.008
riskScore	6.32	2.14–10.50	0.002	5.11	3.12–7.10	0.009
GSE65904 validation dataset
id	HR	95% CI	p-value	HR	95% CI	p-value
age	0.99	0.98–1.01	0.567	1	0.99–1.02	0.592
gender	1.37	0.90–1.84	0.143	1.31	0.86–1.76	0.205
stage	2.35	1.53–3.17	8.55E-05	2.77	1.78–3.76	5.53E-06
riskScore	1.76	1.34–2.18	4.48E-05	1.98	1.49–2.47	1.87E-06
GSE59455 validation dataset
id	HR	95% CI	p-value	HR	95% CI	p-value
age	0.99	0.98–1.00	0.177	0.99	0.98–1.00	0.112
gender	1.24	0.84–1.64	0.283	1.17	0.80–1.54	0.421
stage	0.77	0.67–0.87	0	0.76	0.66–0.86	8.68E-05
riskScore	1.35	0.78–1.92	0.141	1.64	0.94–2.34	0.042
GSE22153 validation dataset
id	HR	95% CI	p-value	HR	95% CI	p-value
age	1.01	0.99–1.03	0.372	1.01	0.99–1.03	0.547
gender	0.99	0.55–1.43	0.967	1.32	0.71–1.93	0.378
stage	1.69	0.66–2.72	0.27	1.05	0.33–1.77	0.938
riskScore	1.95	1.15–2.75	0.013	2.07	1.16–2.98	0.014