Table 3.
20 publications found in addition to those of Table 2, using broader PubMed search terms ( Supplementary Figure 1 ). Only those found relevant to the present chronic GvHD review have been listed.
| Publication | Gene | Population | Genome | Graft | N | Variation | Allele/genotypea | Statistic | 95% CI | P |
|---|---|---|---|---|---|---|---|---|---|---|
| Norden et al. (28) | GR | EUR | D | MRD | 458 pairs | rs6198, rs33388, rs33389 | non-ACT | OR 0.374 | 0.16–0.85 | 0.025 |
| Kielsen et al. (29) | IL-7Rα | EUR | D | MRD, MUD, URD | 460 donors | rs6897932 | T | HR 2.0 | 1.1–3.6 | 0.025 |
| Takahashi et al. (30) | NLRP3 | Japanese | D | MUD | 677 pairs | rs10925027 | T x HLA-C MM | SHR 2.02 | 1.30–3.13 | 0.002 |
| Inamoto et al. (31) | BANK1 | US | D | MRD, MUD, MMRD, MMUD | 847 recipients, 808 donors | rs10516487 | TT | HR 0.43 | 0.21–0.87 | 0.02 |
| CD247 | D | rs2056626 | GG or GT | HR 1.23 | 1.00–1.51 | 0.04 | ||||
| CD247 | R | rs2056626 | GG or GT | HR 1.24 | 1.01–1.52 | 0.04 | ||||
| HLA-DPA1 | D | rs987870 | CC or CT | HR 2.50 | 1.22–5.11 | 0.01 | ||||
| HLA-DPA1 | R | rs987870 | CC or CT | HR 2.13 | 1.00–4.54 | 0.05 | ||||
| Resende et al. (32) | IL17A | Brazilian | R | MRD, MUD, MMUD | 34 pairs | rs2275913 | AA | NA | NA | 0.03b |
| Guillem et al. (33) | TYMP | EUR | D | MRD | 448 pairs | rs112723255 | GG | HR 1.7 | 1.00–2.70 | 0.039 |
| Shamim et al. (34) | IL-7Rα | Caucasian | D | URD | 590 pairs | rs14944558 | TT | NA | NA | 0.002c |
| D | rs1494555 | GG | NA | NA | 0.004c | |||||
| Clark et al. (35) | BAFF | European-American | R | MRD, MUD | 156 recipients, 153 donors | rs16972217 | A | OR 2.72 | 1.38–5.39 | 0.004 |
| R | rs7993590 | T | OR 2.35 | 1.22–4.55 | 0.011 | |||||
| R | rs12428930 | C | OR 2.53 | 1.27–5.04 | 0.008 | |||||
| R | rs2893321 | G | OR 2.48 | 1.25–4.92 | 0.009 | |||||
| Takami et al. (36) | FCGR3A | Japanese | R | MUD | 99 pairs | rs396991 | T | HR 0.45 | 0.20–0.99 | 0.049 |
| Sellami et al. (37) | CTLA4 | Tunisian | D | MRD | 112 pairs | rs231775 | G | OR 2.58 | 1.05–6.32 | 0.032c |
| Inamoto et al. (38) | CCR9 | Japanese | D | MRD | 167 donors | rs12721497 | AG | HR 4.1 | 1.1–15 | 0.036 |
| Kornblit et al. (39) | HMGB1 | EUR | D | MRD, MMRD, MUD, MMUD | 275 recipients, 274 donors | rs2249825 | G | HR 1.53 | 1.15–2.05 | 0.004d |
| HMGB1 | D | rs3742305 | C | HR 1.57 | 1.18–2.09 | 0.002d | ||||
| HMGB1 | D | rs41376448 | insT | HR 1.57 | 1.17–2.12 | 0.003d | ||||
| Boukouaci et al. (40) | MICA | EUR | R | MRD | 211 pairs | rs1051792 | GG | HR 1.61 | 1.08–2.40 | 0.019 |
| Bertinetto et al. (41) | TNFA | EUR | R | MRD | 77 pairs | rs361525 | GG | NA | NA | 0.027c |
| Laguila Visentainer et al. (42) | IL6 | Brazilian | R | MRD | 118 pairs | rs1800795 | CC | RR 3.87 | 1.01–14.86 | 0.049 |
| IL6 | D | rs1800795 | CC | RR 6.64 | 2.26–19.54 | <0.001 | ||||
| Bogunia-Kubik et al. (43) | IFNγ | EUR | R | RD, URD | 160 recipients | Microsatellite (CA) | 3/3 genotype | OR 3.18 | 1.22–8.27 | 0.018 |
| Stark et al. (44) | TNFR2 | EUR | D | MRD | 104 pairs | rs1061622 | GG | OR 11 | NA | 0.024 |
| Cullup et al. (45) | IL1α | EUR | D | MRD | 98 patients, 94 donors | rs1800587 | T | 0R 4.364 | NA | 0.032e |
| IL1α | D | Intron 6 VNTR | Allele 2 | OR 6.832 | NA | 0.008 | ||||
| IL6 | R | rs1800795 | GG | OR 5.603 | NA | 0.016 | ||||
| Cavet et al. (46) | IL6 | EUR | R | MRD | 80 pairs | rs1800795 | GG | OR 4.25 | 1.49–12.16 | 0.007 |
| Takahashi et al. (47) | IL10 | Japanese | Df | MRD + URD | 54 recipients | –1,064 microsatellite, CA repeats | Allele ≥13 | OR 4.5 | 1.3–16.1 | 0.020 |
CI, confidence interval; D, donor; EUR, European; HR, hazard ratio; MMRD, mismatched related donor; MMUD, mismatched unrelated donor; MRD, matched related donor, MUD, matched unrelated donor; NA, not available; OR, odds ratio; R, recipient, RD, related donor; RR, risk ratio; SHR, subdistribution hazard ratio; URD, unrelated donor; US, United States; VNTR, variable number tandem repeat.
aThe effective allele or genotype.
bChi-square test, frequencies only.
cUnivariate analysis, not significant in multivariate analysis.
dResults significant only in the myeloablative cohort, non-significant in the nonmyeloablative cohort.
eNot significant if donor VNTR is also included.
f“Donor-derived”, DNA samples are from recipients after the transplantation.