FIGURE 4.

Multimodal neuroimaging scans in TIGER. (A) Representative dorsal ACC voxel from the MRS scan; (B) Representative rostral ACC voxel from the MRS scan; (C) Representative FreeSurfer-based segmentations of the dorsal ACC (light purple), rostral ACC (dark purple), striatum (orange), hippocampus (yellow), and amygdala (blue); (D) Group-level computations of the salience network anchored in the dorsal ACC (left) and default mode network anchored in the medial prefrontal cortex/rostral ACC and cingulate gyrus (right) derived from resting-state fMRI data using ICA (all maps thresholded at t₆₈ > 3.93; α = 0.0001); (E) Representative tractography of the cingulum bundles (red) and uncinate fasciculus (pink), which are two major white matter tracts that connect fronto-cingulate-limbic structures. ACC, anterior cingulate cortex; ICA, independent components analysis; MRS, magnetic resonance spectroscopy; TIGER, Teen Inflammation Glutamate Emotion Research.