Table 1.

Chemical Inhibitors targeting enzymes of lipid metabolism in ovarian cancer.

Enzyme	Chemical inhibitor	Notes	Pathway	Models(animal/cell line)	Reference
FASN	Orlistat	Reduce proliferation and promotes apoptosis Platinum resensitization	—–	Mouse A2780	(24)
	Compound 34	Inhibits proliferation	—–	A2780	(25)
	Cerulenin or C75 (A cerulenin derived)	Induce apoptosis Platinum resensitization	Receptor/PI3K/mTORC1	SKOV3, OVCAR3, A2780, HOC-7	(26) (27)
	TVB-3664	Reduce tubulin palmitoylation Inhibit proliferation	PI3K/AKT/mTOR β-catenin signal	OVCAR5/8	(28)
	C93	Induce apoptosis	NAC1-FASN	SKOV3, A2780, OVCAR3	(29)
	TVB-3166	Induce apoptosis and anchorage-independent cell growth	PI3K/AKT/mTOR	OVCAR5/8	(28)
SCD1	A939572	Cause cell death	——	SKOV3 Mouse	(30)
	CAY10566	Reduce the lipid unsaturation levels in OC spheroids	STAT/NFκB/SCD1	OVCAR5, COV362	(31)
	MF-438	Induce apoptosis and ferroptosis	—	SKOV3	(30)
	CAY10566	Induce apoptosis and ferroptosis	—–	SKOV3	(30)
ACC1	TOFA	Suppress the proliferation and induce apoptosis. Inhibit growth	Down-regulated the expression of cyclin D1, CDK4 and Bcl-2 Caspase-3 was cleaved and activated.	COC1 Mouse	(32)
MAGL	JZL184	Decrease cancer cell migration	—–	SKOV3, OVCAR3	(33)
CPT	Etomoxir	Reduce tumor growth rate, ascites production	—–	Mouse	(34)
5-LO	Zileuton	Reduce the MMP-7 expression and the number of macrophages infiltrating	P38 pathway	Mouse	(35)
COX2	Celecoxib	Reduce invasion Inhibit proliferation Induce cell cycle arrest in G0/G1 and apoptosis Inhibit tumor growth	COX2/Snail/E-cadherin	1. SKOV3, ES-2 Hey, IGROV1 2. Mouse	(36) (37)
	Berberine	Inhibit the chemotherapy‐induced repopulation of ovarian cancer cells	Caspase3/iPLA2/AA /COX2/PGE2	SKOV3	(38)
FABP4	BMS309403	Reduce tumor burden Increase the sensitivity of carboplatin	—–	Mouse HeyA8, SKOV3	(39)