Figure 1.
Anticancer activity of psychotropic drugs. Two CRC (HCT116 and SW620), 2 BC (MCF7 and MDA-MB-231) and 2 GB (U87MG and U251) cell lines were treated for 72 h with scalar doses of drugs ranging from 10 to 160 μmol/L. The screened drugs included antipsychotics, antidepressant, antihistamines, and three compounds used in scientific research with reported serotonin receptors antagonistic activity (R59949, R59022; WAY-100135). Viabilities were assessed by MTT assay. Data are presented as mean IC50 ± standard error of the mean (SEM) from three-five independent experiments, each performed in quadruplicate. IC50, drug concentration reducing by 50% viability compared to control. Histograms show drugs with IC50 < 100 μmol/L.