TABLE 4.

Overall mortality rate, univariable and multivariable cox regression analyses predicting overall survival in patients with carcinoma of the bladder with variant histology within the SEER between 2004 and 2015.

		Univariable cox regression analyses		Multivariable cox regression analyses
Histologic type	Overall mortality No. (%)	HR (95% CI)	P	HR (95% CI)	P
Transitional cell carcinoma
No PLND	1232 (58.7)	1	<0.001	1	<0.001
PLND	6440 (49.2)	0.830 (0.781–0.882)		0.595 (0.557–0.634)
Squamous cell carcinoma
No PLND	68 (70.1)	1	0.010	1	0.002
PLND	355 (59.4)	0.710 (0.548–0.921)		0.646 (0.494–0.846)
Adenocarcinoma
No PLND	25 (58.1)	1	0.593	1	0.810
PLND	119 (55.3)	1.125 (0.730–1.733)		1.057 (0.671–1.667)
Small cell carcinoma
No PLND	9 (60.0)	1	0.325	1	0.136
PLND	94 (55.6)	0.709 (0.357–1.406)		0.576 (0.279–1.190)
Neuroendocrine carcinoma
No PLND	1 (20.0)	1	0.229	1	0.143
PLND	27 (50.9)	3.408 (0.461–25.177)		6.217 (0.540–71.560)
Signet ring cell carcinoma
No PLND	12 (85.7)	1	0.242	1	<0.001
PLND	60 (70.6)	0.690 (0.371–1.284)		0.233 (0.107–0.504)
Pseudosarcomatous carcinoma
No PLND	4 (44.4)	1	0.289	1	0.992
PLND	34 (75.6)	1.759 (0.619–4.997)		0.994 (0.307–3.219)
Other
No PLND	22 (61.1)	1	0.378	1	0.324
PLND	72 (60.0)	0.807 (0.500–1.301)		0.727 (0.386–1.369)
Overall
No PLND	1373 (59.3)		<0.001	1
PLND	7201 (50.1)	0.833 (0.786–0.882)		0.601 (0.565–0.639)	<0.001

95% CI, 95% confidence interval; HR, hazard ratio; PLND, pelvic lymph node dissection.