Table 2.
Single-nucleotide variants resulting in coding sequence changes detected in two or more remdesivir-selected passage 35 rEBOV/ZsG lineages
| Gene and SNV ID | VP35 G4056A | L T13984C | L A14025G | L A14620G | |
| Virus ID | CDS change | S310N | F548S | T562A | E760V |
| RDV-1 | % SNV freq. | 94.31 | 62.61 | ||
| read depth | 562 | 591 | |||
| RDV-2 | % SNV freq. | 97.99 | 100 | 52.57 | |
| read depth | 1,197 | 583 | 1,090 | ||
| RDV-3 | % SNV freq. | 100 | 73.51 | ||
| read depth | 666 | 823 | |||
| RDV-4 | % SNV freq. | 39.23 | 98.67 | ||
| read depth | 181 | 75 | |||
| RDV-5 | % SNV freq. | 100 | 54.53 | 52.76 | |
| read depth | 236 | 237 | 326 | ||
| RDV-6 | % SNV freq. | 99.89 | 47.37 | ||
| read depth | 934 | 1,503 |
Reference sequence for rEBOV/ZsG: GenBank accession number KR781609.1. Freq., frequency. Cutoff frequency for SNV detection, 15%. CDS, coding sequence; SNV, single-nucleotide variant.