Table 2.
Association of various genomic profiles of H. pylori with gastric cancer.
| GI | Function | Validation set 1 | Validation set 2 | ||||
|---|---|---|---|---|---|---|---|
| H. pylori isolated from 9 gastric cancer patients | H. pylori isolated from 29 subjects without gastric cancer | P-value | H. pylori isolated from 16 gastric cancer patients | H. pylori isolated from 123 subjects without gastric cancer | P-value | ||
| Protein also detected in exploratory dataset | |||||||
| 983282765 (OA23_04715) | Integrase | 8 (88.89) | 15 (51.72) | 0.1091* | 14 (87.5) | 60 (48.78) | 0.007963 |
| Odds ratio (95% confidence interval) | 7.47 (0.83, 57.51) | 7.35 (1.6, 33.71) | |||||
| Proteins detected only in validation sets | |||||||
| 983282771 (OA23_04830) | DNA topoisomerase I | 8 (88.89) | 12 (41.38) | 0.03472 | 11 (68.75) | 73 (59.35) | 0.6516 |
| Odds ratio (95% confidence interval) | 11.33 (1.25, 102.93) | 1.51 (0.49. 4.6) | |||||
| 983282996 (OA23_06705) | Hypothetical protein | 8 (88.89) | 12 (41.38) | 0.03472 | 12 (75) | 72 (58.54) | 0.3197 |
| Odds ratio (95% confidence interval) | 11.33 (1.25, 102.93) | 2.13 (0.65, 6.96) | |||||
| 447057575 (OA23_04675) | Hypothetical protein | 6 (66.67) | 15 (51.72) | 0.6863 | 11 (68.75) | 26 (21.14) | 0.0001748 |
| Odds ratio (95% confidence interval) | 1.6 (0.33, 7.77) | 8.21 (2.62, 25.72) | |||||
| 447147459 | Haloacid dehalogenase | 7 (77.78) | 13 (44.83) | 0.1779 | 10 (62.5) | 71 (57.72) | 0.9243 |
| Odds ratio (95% confidence interval) | 4.31 (0.76, 24.38) | 7.32 (0.91, 59.01) | |||||
| 983282632 | Lipopolysaccharide biosynthesis protein | 6 (66.67) | 15 (51.72) | 0.6863 | 12 (75) | 71 (57.72) | 0.2917 |
| Odds ratio (95% confidence interval) | 1.87 (0.39, 8.93) | 2.2 (0.67, 7.2) | |||||
| 446412707 | Sulfatase | 6 (66.67) | 10 (34.48) | 0.1862 | 11 (68.75) | 51 (41.46) | 0.07215 |
| Odds ratio (95% confidence interval) | 3.8 (0.78, 18.51) | 3.11 (1.02, 9.48) | |||||