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. 2020 Oct 19;11:554301. doi: 10.3389/fimmu.2020.554301

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Copyright © 2020 Liu, Saredy, Zhang, Shao, Sun, Yang, Wang, Liu, Drummer, Johnson, Saaoud, Lu, Xu, Li, Wang, Jiang, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The up- and down-regulated innatomic genes (IGs) share inflammatory diseases in deficiencies of proinflammatory cytokines (PCs). (A) The upregulated IGs in PCs KO microarrays share 8 different diseases and disorders including inflammatory diseases. (B) The down-regulated IGs in PCs KO microarrays share 7 different diseases and disorders including infectious diseases (increased) and inflammatory diseases. (C) Venn diagram showed the upregulated IGs and the downregulated IGs share 11 diseases or disorders, two diseases or disorders included exclusively in “Up-regulated IGs” and five disease or disorders included exclusively in “Down-regulated IGs”. In them, cardiovascular disease is shared in up- and down-regulated IGs.