Table 3B.

IPA results showed the significant pathways (∣Z score∣> 2) of down-regulated IGs in pro-inflammatory cytokine KO microarray datasets.

No.	Significant signaling pathways	Tnfr1,2-/- (GSE33253)	Ifng-/- (GSE9892)	Ifngr1-/- (GSE39592)	Il18-/- (GSE64309)
1	Dendritic Cell Maturation	↓	↓	↓	↓
2	Cardiac Hypertrophy Signaling (Enhanced)	↓	↓	↓
3	Systemic Lupus Erythematosus In B Cell Signaling Pathway	↓	↓	↓
4	Interferon Signaling	↓	↓	↓
5	Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses	↓	↓	↓
6	TREM1 Signaling	↓	↓	↓
7	Neuroinflammation Signaling Pathway	↓	↓	↓
8	iNOS Signaling	↓	↓	↓
9	p38 MAPK Signaling	↓	↓	↓
10	Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	↓	↓	↓
11	Colorectal Cancer Metastasis Signaling	↓	↓	↓
12	PI3K Signaling in B Lymphocytes	↓	↓	↓
13	IL-1 Signaling	↓	↓	↓
14	Adrenomedullin signaling pathway	↓	↓		↓
15	Cholecystokinin/Gastrin-mediated Signaling	↓	↓		↓
16	Toll-like Receptor Signaling		↓	↓	↓
17	HGF Signaling	↓	↓
18	Tec Kinase Signaling	↓	↓
19	MIF Regulation of Innate Immunity	↓	↓
20	NF-κB Activation by Viruses	↓	↓
21	Signaling by Rho Family GTPases	↓	↓
22	ERK/MAPK Signaling	↓	↓
23	IL-8 Signaling	↓	↓
24	PI3K/AKT Signaling	↓	↓
25	PKCθ Signaling in T Lymphocytes	↓	↓
26	Endothelin-1 Signaling	↓	↓
27	Synaptogenesis Signaling Pathway	↓	↓
28	ILK Signaling	↓	↓
29	PDGF Signaling	↓	↓
30	Activation of IRF by Cytosolic Pattern Recognition Receptors	↓		↓
31	IL-6 Signaling	↓		↓
32	Th17 Activation Pathway	↓		↓
33	JAK/Stat Signaling	↓		↓
34	NF-κB Signaling			↓	↓
35	HMGB1 Signaling		↓	↓
36	Cardiac Hypertrophy Signaling		↓	↓
37	Acute Phase Response Signaling			↓	↓
38	Rac Signaling	↓
39	B Cell Receptor Signaling	↓
40	Ephrin Receptor Signaling	↓
41	Role of IL-17F in Allergic Inflammatory Airway Diseases	↓
42	PPAR Signaling	↑
43	Leukocyte Extravasation Signaling	↓
44	TNFR1 Signaling	↓
45	MIF-mediated Glucocorticoid Regulation	↓
46	Integrin Signaling	↓
47	RhoA Signaling	↓
48	Type II Diabetes Mellitus Signaling	↓
49	Cdc42 Signaling	↓
50	Antioxidant Action of Vitamin C	↑
51	iCOS-iCOSL Signaling in T Helper Cells	↓
52	FAT10 Cancer Signaling Pathway	↓
53	PAK Signaling	↓
54	Type I Diabetes Mellitus Signaling	↓
55	Renin-Angiotensin Signaling	↓
56	CD28 Signaling in T Helper Cells	↓
57	IL-7 Signaling Pathway	↓
58	LPS-stimulated MAPK Signaling	↓
59	Fc Epsilon RI Signaling		↓
60	cAMP-mediated signaling		↓
61	Osteoarthritis Pathway		↓
62	Hepatic Fibrosis Signaling Pathway		↓
63	T Cell Exhaustion Signaling Pathway		↓
64	Oncostatin M Signaling		↓
65	Unfolded protein response		↓
66	Retinoic acid Mediated Apoptosis Signaling		↓
67	LXR/RXR Activation		↑
68	Role of NFAT in Regulation of the Immune Response		↓
69	PPARα/RXRα Activation		↑
70	RhoGDI Signaling		↑

A total of 10 microarrays about proinflammatory cytokines in Supplementary Table 2A were analyzed, GSE43145, GSE73875, GSE88800, GSE64309, GSE63761, GSE64308 and GSE64310 were not included because there were no significant (∣Z score∣< 2) pathways in them. The data showed a total of 37 shared significant signaling pathways of the down-regulated innate immune genes in the inflammatory cytokines KO microarrays. According to the IPA classification, 19 cellular immune response signals (marked in bold) are down-regulated by the PCs KO. And in 33 unique significant signaling pathways, 8 cellular immune response signals (marked in bold) were suppressed when one PCs was KO. The detailed IPA results were showed in Table S8 .