Table 5.
165 ROS regulators were analyzed in inflammatory molecules KO microarrays.
| No. | PCs and regulators | GEO NO. | Method | ROS regulators | |||||
|---|---|---|---|---|---|---|---|---|---|
| Up-regulated | Down-regulated | ||||||||
| N | % | Genes | N | % | Genes | ||||
| Proinflammatory cytokines | |||||||||
| 1 | TNF | GSE43145 | Tnfa KO | 3 | 2.42 | Bst1,Cryab,Foxm1 | 4 | 2.42 | Ncf1,Noxo1,Sod1,Tlr2 |
| 2 | GSE33253 | Tnfr1,2 KO | 4 | 2.42 | Cyp1b1,Nfe2l2,Sirt5,Tgfbr2 | 13 | 7.88 | Acod1,Cd36,Cps1,Crp,Cybb,Ddit4, Edn1,Fpr2,Mmp3,Ncf1,Pdgfb,Sesn1,Tnf |
|
| 3 | IFNG | GSE9892 | Ifng KO | 7 | 4.24 | Ace2,Bmp7,Egfr,Fbln5,Mapt, Noxo1,Sod1 |
14 | 8.48 | Acod1,Apoa4,Bnip3,Bst1,Cybb, Fpr2,Hk2,Nos2,P2rx7,Sftpd,Sod3, Tfap2a,Xdh,Zc3h12a |
| 4 | GSE39592 | Ifngr1 KO | 10 | 6.06 | Cd177,Cdkn1a,Cps1,Cyp1b1, Mapt,Mt3,Pdgfb,Pla2r1,Sesn2, Sod1 |
11 | 6.67 | Acod1,Bco2,Bmp7,Bst1,Cryab, Foxm1,Fpr2,Gls2,Ncf1,P2rx7,Sirt5 |
|
| 5 | IL1B | GSE15750 | Traf6 KO | 0 | 0.00 | N/A | 2 | 1.21 | Coq7,Syk |
| 6 | GSE73875 | Irak1 KO | 3 | 1.82 | Cybb,Fpr2,Tyrobp | 0 | 0.00 | N/A | |
| 7 | IL6 | GSE63761 | Il6 KO | 11 | 6.67 | Cyba,Gch1,Itgam,Itgb2,Ncf1, Ncf4,Nfe2l2,Prkcd,Tlr6,Tyrobp, Vav1 |
3 | 1.82 | Agt,Ddit4,Nos3 |
| 8 | IL17 | GSE88800 | Il17ra KO | 23 | 13.94 | Acod1,Cd177,Cdkn1a,Ddit4, Edn1,Fpr2,Gch1,Hif1a,Itgam, Mmp3,Mpo,Mt3,Ncf1,Ncf4, Nos2,Pdk4,Pon3,Rac2,Ripk3, Sh3pxd2b,Thbs1,Tlr6,Tnf |
3 | 1.82 | Bco2,Mapt,Tigar |
| 9 | IL18 | GSE64308 | Il18 KO | 6 | 3.64 | Cdkn1a,Duox1,Edn1,F2, Rgn,Thbs1 |
1 | 0.61 | Alox12 |
| 10 | GSE64309 | Il18 KO | 7 | 4.24 | Apoa4,Cdkn1a,Ddit4,Gstp1, Mpo,Pax2,Pdk4 |
8 | 4.85 | Bco2,Bnip3,Cd36,Duox1,Gadd45a, Itgam,Lep,Nqo1 |
|
| 11 | GSE64310 | Il18 KO | 1 | 0.61 | Apoa4 | 2 | 1.21 | Bco2,Sh3pxd2a | |
| ProInflammatory related transcription factor | |||||||||
| 12 | STAT | GSE40666 | Stat1 KO | 6 | 3.64 | Cd36,Cdkn1a,Mt3,Pmaip1, Sirt3,Syk |
0 | 0.00 | N/A |
| 13 | GSE6846 | Stat3 KO | 8 | 4.85 | Cybb,Hif1a,Itgam,Mapk14, Ncf1,Pla2r1,Syk,Tyrobp |
3 | 1.82 | Brca1,Plin5,Sod1 | |
| 14 | NFKB | GSE45755 | Rela KO | 6 | 3.64 | Cybb,Mpo,Ncf1,Ncf4,Tspo, Tyrobp |
0 | 0.00 | N/A |
| 15 | GSE30049 | Ikk2 KO | 9 | 5.45 | Bcl2,Bmp7,Cryab,Cyp1b1, Immp2l,Nox4,Pdk4,Prex1, Thbs1 |
12 | 7.27 | Brca1,Cybb,Dhfr,Edn1,Ephx2,F2rl1, Gch1,Nos2,Pdgfb,Prcp,Ripk3,Sod3 |
|
| Inflammatory-related miRNAs | |||||||||
| 16 | MIR155 | GSE45122 | mir155 KO | 3 | 1.82 | Bmp7,Crp,Nqo2 | 3 | 1.82 | Cyp1b1,Lrrk2,Pax2 |
| 17 | GSE66815 | mir155 KO | 13 | 7.88 | Alox12,Bst1,Cyp1b1,Lrrk2, Ncf2,Nos3,Pmaip1,Prex1,Rac2,Sesn1,Syk,Vav1,Zc3h12a |
10 | 6.06 | Agt,Cd177,Cdkn1a,Egfr,Foxm1, Hif1a,Noxo1,Nqo1,Sirt2,Vdac1 |
|
| 18 | MIR221 | GSE19777 | MIR221 KD | 1 | 0.61 | CPS1 | 4 | 2.42 | ACOD1,CYBB,PLA2R1,SFTPD |
Table S11 listed the detail expression changes of ROS regulator. (p < 0.05, ∣log2FC∣>1).