Figure 3.
Human hematopoietic output is dependent on HSPC dose. The relative abundance and kinetics of human HSPC expansion in NBSGW mice was determined for each graft source. (A) Total number of human cells in the bone marrow collected from one leg (femur + tibia) at 12 weeks post-transplantation according to the starting HSPC dose. Symbols show individual mice that received HSPCs isolated from CB (blue), BM (red), or MB (green), with lines indicating geometric means. (B) Total number of human cells in the murine spleens at 12 weeks post-transplantation. (C) Total number of human cells in 100 μl of murine peripheral blood, collected at the indicated times post-transplantation. Results are from transplantation of 5E5 HSPCs. *p < 0.05; **p < 0.01; ***p < 0.001.