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. 2020 Oct 28;16:2519–2528. doi: 10.2147/NDT.S270614

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© 2020 Zhang et al.

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LncRNA MEG3 ameliorated progression of epilepsy and activated the PI3K/AKT/mTOR pathway. (A) RT-qPCR was used to detect the mRNA expression of MEG3 in the hippocampus tissue of rats. (B–D) RT-qPCR was used to detect the mRNA expression of IL-1β (B), IL-6 (C) and TNF-α (D) in the hippocampus tissue of rats. (E) Malondialdehyde (MDA) content in the hippocampus tissue of rats. (F) Superoxide dismutase (SOD) activity in the hippocampus tissue of rats. (G) The apoptosis of hippocampal neurons was detected using TUNEL assay. (H) The expression of proteins related to apoptosis (Caspase-3, Bax and Bcl-2) was detected using Western blot. (I) The expression of proteins related to the PI3K/AKT/mTOR pathway was detected using Western blot. **P < 0.01 vs TLE and TLE+NC group.