Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 28;14:4533–4546. doi: 10.2147/DDDT.S258973

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Yang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

SAMC influenced the inflammatory cytokines expression and NF-κB activity in OA rat. (A) Pro-inflammatory cytokines, TNF-α, IL-1β, IL-6 have elevated in OA rats, while SAMC treatment down-regulated these cytokines in joint cavity fluid, n=8. (B) Q-PCR detection of TNF-α, IL-1β, IL-6 mRNA level, n=4. (C) In articular cartilage, the elevated level of COX-2 and iNOS were down-regulated by the treatment of SAMC, n=4. (D) The nuclear NF-κB p65 in articular cartilage protein increased in OA rats, accompanied with IκBα degradation increased in cytoplasmic protein, n=4. SAMC treatment reversed the NF-κB activation by preventing p65 translocated to nucleus exanimated by immunohistochemistry, n=4, Scale bar: 100 μm (E). *P<0.05, vs Sham; ^#P<0.05, vs OA. n=8.