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. 2020 Oct 28;14:4533–4546. doi: 10.2147/DDDT.S258973

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© 2020 Yang et al.

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Nrf2 deficiency influences the protecting effect of SAMC in chondrocytes matrix destruction in OA chondrocytes. Expression of miNrf2 on the effect of SAMC on Col II (A) expression and the MMPs (MMP-2, MMP-9, MMP-13) and TIMP-1 (B) expression in IL-1β-induced OA chondrocytes; also, MMPs/TIMP-1 ratios was calculated. *P<0.05, vs Ad-scramble. Experiments were performed in triplicate.