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. 2020 Oct 28;14:4533–4546. doi: 10.2147/DDDT.S258973

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© 2020 Yang et al.

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SAMC targets Nrf2 to mediate NF-κB regulated inflammatory pathway in OA chondrocytes. (A) COX2 and iNOS expression were up-regulated after IL-1β stimulation, but attenuated by SAMC treatment; but the protective effect was inhibited in Nrf2-deficient OA chondrocytes. (B) Western Blot analysis of p65 in nuclear and IκBα in cytoplasm protein level. *P<0.05, vs Ad-scramble. Experiments were performed in triplicate.