Fig. 1.

Anti-apoptotic properties of minocycline (Min), which has the potential to suppress apoptotic signals in cells. By acting on the extrinsic pathway of apoptosis activation, Min can inhibit the activation of caspase-7, a caspase with pro-apoptotic activity. In the intrinsic pathway of apoptosis activation, Min can inhibit oligomerization of pro-apoptotic mitochondrial proteins (Bax/Bak) and the export of cytochrome C and Smac/Diablo, blocking activation of caspase 9 and its effect on caspase 3activation. Min also blocks the apoptotic effect of caspase 3