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Effect of tetracyclines on the NF-κB transcription factor pathway. Minocycline (Min) and doxycycline (Dox) are capable of inhibiting the NF-κB pathway, acting on different points of this activation by inhibiting IκBα (IKK) activation, IκBα phosphorylation, degradation and p65, and nuclear translocation of NF-κB, leading to a decreased pro-inflammatory immune response
