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Von Willebrand factor–related pathophysiology for arterial and microvascular thrombosis in acute thrombotic thrombocytopenic purpura and atherosclerotic cardiovascular disease, and mechanisms for thrombus prevention by aptamers and antibodies to VWF A1 domain. VWF: von Willebrand factor; UL: ultralarge; ADAMTS13: a disintegrin and metalloproteinase with thrombospondin type 1 repeats, member 13; GPIb: glycoprotein Ib.
