Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
MEN1309/OBT076 combined with the BCL2 inhibitor venetoclax and the anti-CD20 monoclonal antibody rituximab exerts cytotoxicity downregulating MCL1, cleaving PARP and upregulating CD20 protein. Two cell lines were exposed to MEN1309/OBT076 (1nM), venetoclax (100 nM), rituximab (20 g/mL) or the combination of the agents for 72 hours. -tubulin was used as a loading control. Figure is representative of two independent experiments.
