Table 2.
Univariate and multivariate analyses of risk factors related to RFS in HCC patients.
| Clinical factor | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Gender (male vs. female) | 0.656 | 0.300-1.440 | 0.294 | |||
| Age | 0.999 | 0.977-1.022 | 0.940 | |||
| ALT (<=50 U/L vs. >50 U/L) | 1.022 | 0.617-1.694 | 0.931 | |||
| Main tumor size(<=5 cm vs. >5 cm) | 1.620 | 0.958-2.740 | 0.072 | |||
| Multinodular (no vs. yes) | 1.556 | 0.871-2.782 | 0.135 | |||
| Cirrhosis (no vs. yes) | 3.428 | 0.838-14.022 | 0.087 | |||
| AVR-CC (no vs. yes) | 0.700 | 0.386-1.269 | 0.240 | |||
| CLIP stage (0 vs. 1-5) | 0.848 | 0.517-1.391 | 0.514 | |||
| TNM stage (I+II vs. III+IV) | 1.758 | 1.242-2.489 | 0.001 | 1.359 | 0.906-2.038 | 0.138 |
| BCLC stage | 2.586 | 1.545-4.331 | <0.001 | 1.926 | 1.070-3.469 | 0.029 |
| AFP (<=300 ng/ml vs. >300 ng/ml) | 0.784 | 0.477-1.287 | 0.335 | |||
| Risk score | 1.316 | 1.161-1.491 | <0.001 | 1.313 | 1.153-1.497 | <0.001 |
Abbreviations: AVR-CC: active viral replication chronic carrier; ALT: alanine aminotransferase; TNM: tumor node metastasis; CLIP: cancer liver Italian program; BCLC: Barcelona Clinic Liver Cancer; AFP: alpha-fetoprotein.