TABLE 1.
Critical sites for enzymatic activity of HSD17B13
| Protein Name | Enzymatic Activity | Possible Reason for Loss of Activity |
| HSD17B13 | Yes | NA |
| HSD17B13-variant B | No | Nonlipid droplet targeting/low protein stability |
| HSD17B13-Δ22-28 | No | Nonlipid droplet targeting/low protein stability |
| HSD17B13-Δexon 6 | No | Not known |
| HSD17B13-G insertion | No | Not known |
| HSD17B13-P260S | No | Not known |
| HSD17B13-G47A/G49A | No | Impaired cofactor binding |
| HSD17B13-N144A | No | Impaired catalytic site/low protein stability |
| HSD17B13-S172A | No | Impaired catalytic site |
| HSD17B13-Y185A/K189A | No | Impaired catalytic site |
| HSD17B13-L199A/E202A | No | Impaired substrate binding/low protein stability |
| HSD17B13-K208A | No | Impaired substrate binding |
| HSD17B13-K153A/L156A | No | Impaired substrate binding/low protein stability |
| HSD17B13-R97A/Y101A | No | Impaired dimer formation |