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. Author manuscript; available in PMC: 2021 Jan 24.
Published in final edited form as: Annu Rev Pathol. 2020 Jan 24;15:179–209. doi: 10.1146/annurev-pathmechdis-012419-032756

Figure 1.

Figure 1.

Development of the eosinophil lineage in the context of normal human hematopoiesis. In the current paradigm, hematopoietic stem cells (HSC) give rise directly to eosinophil/mast cell progenitors (EoMP), from which IL-5R+ eosinophil progenitors (EoPs) develop and terminally differentiate into mature eosinophils. EoMPs also differentiate into basophil progenitors (BaP) and mast cells. Expression of GATA-1 versus Flt3 distinguishes between early multipotent progenitors that give rise to EoMP and megakaryocyte/erythroid progenitors (MEP) versus common lymphoid progenitors (CLP) and neutrophil/macrophage progenitors (NMP) (formerly GMP). Both NMP and MEP arise from a common myeloid progenitor (CMP) distinct from the EoMP population.