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. 2020 Nov 2;20:400. doi: 10.1186/s12883-020-01971-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — MRI of Case 4. Tumefactive BCS-type lesion in the right centrum semiovale (A and B thick arrow) with incomplete central solid Gd + along with incomplete ring-like Gd + of the outer two layers (C thick arrow) and multiple typical non-enhancing MS lesions supratentorially (A thins arrows). BCS-type lesion with effacement of the “onion bulb” pattern (D and E thick arrow) 2 months after BCS onset and after corticosteroid treatment. BCS-type lesion (F thick arrow) at the 7th month of natalizumab treatment and 13th from the onset. a, d: FLAIR images. b, e: T2-weighted images. c: T1-weighted contrast-enhanced images. f: 3D FLAIR image. BCS: Baló’s concentric sclerosis, Gd+: gadolinium enhancement