Table 1.

Synopsis of clinical, radiologic, laboratory and therapeutic characteristics in 8 patients with BCS

Case	Age at onset (years)	Sex	Symptoms at BCS onset	BCS-type lesion size (cm) at onset	Pattern of BCS-type lesion Gd+	Coexistence of brain MS-like plaques	Barkof criteria fulfillment at BCS onset	Spinal cord lesions at BCS onset	CSF OCBs	Time to follow-up from BCS onset (months)	Response to IVMP	Long-term Treatment
1	24	M	right-sided hemiparesis and hemianaesthesia	2.8	Peripheral Gd + at outer layer	(+)	No	(−)	(+)	85	poor	CYC
2	30	F	dysarthria,left facial palsy, left hand dexterity problems	3.6	Peripheral ring-like Gd + at outer layer	(−)	No	(−)	(+)	34	poor	CYC
3	41	M	Wernicke’s aphasia and right-sided hemianaesthesia	2.6	Peripheral ring-like Gd + at outer two layers	(+)	No	(−)	Not tested	132	poor	1st MTX 2nd GA
4	18	F	blurred vision	3.1	Peripheral incomplete ring-like Gd + at outer two layers	(+)	Yes	(−)	(+)	16	excellent	1st GA, 2nd NTZ
5	18	F	right-sided hemiparesis	2	Peripheral ringlike Gd + at outer layer	(+)	Yes	(+)	Not tested	127	good	1st IFN-beta-1b, 2nd NTZ
6	26	M	dysarthria	3.6	Peripheral incomplete ringlike Gd + at outer two layers	(+)	Yes	(−)	(−)	23	poor	RTX
7	26	F	gait instability, mild left hemiparesis	1.7	peripheral Gd + at outer layer	(+)	No	(+)	(+)	29	poor	RTX
8	27	M	left facial nerve palsy	1.8	partial ringlike Gd+	(+)	No	(−)	(−)	9	poor	CYC

Abbreviations: BCS Baló’s Concentric Sclerosis, F Female, M: Male, Gd+ Gadolinium Enhancement, CSF OCBs Cerebrospinal Fluid Oligoclonal Bands, (+) presence, (−) absence, MS Multiple Sclerosis, IVMP intravenous methylprednisolone, CYC Cyclophosphamide, MTX Mitoxantrone, RTX Rituximab, GA Glatiramer acetate