Table 2.
Diagnostic performances of AFP, DCP, and AFP-L3 for hepatitis B virus-associated hepatocellular carcinoma
| AUC (95%CI) | Cut-off | SEN | SPE | PPV | NPV | |
|---|---|---|---|---|---|---|
| AFP | 0.76 (0.69,0.83) | 10 (ng/mL) | 51.5% | 92.5% | 91.1% | 56.4% |
| AFP-L3 | 0.62 (0.53,0.71) | 0.1 | 28.3% | 95.5% | 90.3% | 47.4% |
| DCP | 0.75 (0.67,0.83) | 38 (mAU/mL) | 60.0% | 84.7% | 87.0% | 55.6% |
| AFP + DCP | 0.81 (0.74,0.88) | 0.49* | 67.0% | 83.1% | 87.0% | 59.8% |
| AFP + AFP-L3 | 0.76 (0.69,0.83) | 0.51* | 53.5% | 89.6% | 88.3% | 56.6% |
| AFP + AFP-L3 + DCP | 0.81 (0.75,0.88) | 0.48* | 66.7% | 83.1% | 86.8% | 59.8% |
AFP, alpha-fetoprotein; AFP-L3, Lens culinaris agglutinin-reactive AFP; DCP, des-gamma-carboxy-prothrombin; AUC, area under the curve; CI: confidence interval; SEN, sensitivity; SPE, specificity; PPV, positive predictive value; NPV, negative predictive value
*The optimal probability was calculated by applying the logistic regression model that showed the highest value of sensitivity + specificity−1.