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. 2020 Oct 8;76(Pt 11):508–516. doi: 10.1107/S2053230X20012297

Figure 4.

Figure 4

Comparison of the P140 C-domain structures. (a) Two views (90° apart from each other) of the superposed C-domain structures as found in this work (green) and in the structure of the whole P140 ectodomain (PDB entry 6s3u; red; Aparicio et al., 2020 ▸). The largest differences are found in the N- and C-­terminal tails and in the β-bulge. (b) The presence of the P140 N-domain would clash with the C-domain β-bulge as seen in this work, suggesting that movement of the β-­bulge can be associated with movement of the N- and C-­domains with respect to one another. (c) The insets show details of the interactions found in the whole P140 ectodomain structure that occur in the N-terminal end with either residues Leu1290 and Asn1291 (left) or with the β-bulge (right). (d) Scheme of the possible transition between the C-domain structures found in this work and in the whole P140 ectodomain. Disturbing the interactions of the N-terminus from the whole P140 ectodomain structure would destabilize this region, which in turn would eliminate the interactions with the β-­bulge.