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JAK2V617F mice show prolonged time to occlusion in a FeCl3 model of vascular injury, as well as prolonged bleeding. A. Carotid artery injury was performed on WT (n = 8) and JAK2V617F (n= 9) male mice. tOc for each mouse in shown. Black circles represent mice 12 weeks old, open circles represent mice age 30 weeks old. Data are averages +/− SD. B. Tail bleeding assay of WT (n = 9) and JAK2V617F (n = 9) male mice 14–20 weeks old. ** p < 0.01, **** p < 0.0001, unpaired two-tailed t-test.
