Table 1.
Wild-Type Normoxia versus Chronic Hypoxia Right Ventricle
| GO Term | Description | P Value | FDR q Value | Enrichment |
|---|---|---|---|---|
| GO process (log fold change >1.5) | ||||
| GO:0007186 | G-protein–coupled receptor signaling pathway | 3.47 × 10−5 | 4.90 × 10−1 | 2.79 |
| GO:0007154 | Cell communication | 1.03 × 10−4 | 7.24 × 10−1 | 2.45 |
| GO:0007218 | Neuropeptide signaling pathway | 1.39 × 10−4 | 6.54 × 10−1 | 13.86 |
| GO:0060428 | Lung epithelium development | 2.61 × 10−4 | 9.19 × 10−1 | 20.8 |
| GO:0003008 | System process | 2.71 × 10−4 | 7.63 × 10−1 | 1.91 |
| GO:0043269 | Regulation of ion transport | 2.90 × 10−4 | 6.82 × 10−1 | 2.22 |
| GO:0002684 | Positive regulation of immune system process | 4.59 × 10−4 | 9.25 × 10−1 | 2.01 |
| GO:1903814 | Regulation of collecting lymphatic vessel constriction | 5.76 × 10−4 | 1.00 × 1 | 41.59 |
| GO: 0021941 | Negative regulation of cerebellar granule cell precursor proliferation | 5.76 × 10−4 | 9.03 × 10−1 | 41.59 |
| GO:0009786 | Regulation of asymmetric cell division | 5.76 × 10−4 | 8.13 × 10−1 | 41.59 |
| GO:0051610 | Serotonin uptake | 5.76 × 10−4 | 7.39 × 10−1 | 41.59 |
| GO:0060481 | Lobar bronchus epithelium development | 5.76 × 10−4 | 6.77 × 10−1 | 41.59 |
| GO:0023052 | Signaling | 5.89 × 10−4 | 6.39 × 10−1 | 2.64 |
| GO:0007189 | Adenylate cyclase-activating G-protein–coupled receptor signaling pathway | 6.79 × 10−4 | 6.84 × 10−1 | 5.55 |
| GO:0060638 | Mesenchymal-epithelial cell signaling | 7.04 × 10−4 | 6.62 × 10−1 | 15.6 |
| GO:0007267 | Cell–cell signaling | 8.71 × 10−4 | 7.68 × 10−1 | 2.77 |
| GO:0006811 | Ion transport | 8.75 × 10−4 | 7.26 × 10−1 | 1.85 |
| GO:0007155 | Cell adhesion | 8.79 × 10−4 | 6.89 × 10−1 | 2.02 |
| GO:0007187 | G-protein–coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 9.09 × 10−4 | 6.75 × 10−1 | 3.96 |
| GO function (log fold change >1.5) | ||||
| GO:0048018 | Receptor ligand activity | 2.53 × 10−8 | 1.03 × 10−4 | 4.42 |
| GO:0030545 | Receptor regulator activity | 8.48 × 10−8 | 1.72 × 10−4 | 4.12 |
| GO:0060089 | Molecular transducer activity | 7.11 × 10−7 | 9.63 × 10−4 | 2.6 |
| GO:0038023 | Signaling receptor activity | 8.01 × 10−7 | 8.14 × 10−4 | 2.69 |
| GO:0004888 | Transmembrane signaling receptor activity | 1.51 × 10−6 | 1.23 × 10−3 | 2.93 |
| GO:0022836 | Gated channel activity | 3.20 × 10−6 | 2.17 × 10−3 | 4.16 |
| GO:0022839 | Ion gated channel activity | 8.05 × 10−6 | 4.67 × 10−3 | 4.1 |
| GO:0005216 | Ion channel activity | 2.32 × 10−5 | 1.18 × 10−2 | 3.36 |
| GO:0022838 | Substrate-specific channel activity | 2.97 × 10−5 | 1.34 × 10−2 | 3.29 |
| GO:0022803 | Passive transmembrane transporter activity | 5.98 × 10−5 | 2.43 × 10−2 | 3.11 |
| GO:0015267 | Channel activity | 5.98 × 10−5 | 2.21 × 10−2 | 3.11 |
| GO:0005261 | Cation channel activity | 6.63 × 10−5 | 2.25 × 10−2 | 3.6 |
| GO:0070492 | Oligosaccharide binding | 9.46 × 10−5 | 2.96 × 10−2 | 15.12 |
| GO:0022832 | Voltage-gated channel activity | 1.10 × 10−4 | 3.20 × 10−2 | 4.29 |
| GO:0005244 | Voltage-gated ion channel activity | 1.10 × 10−4 | 2.98 × 10−2 | 4.29 |
| GO:0050840 | Extracellular matrix binding | 1.56 × 10−4 | 3.97 × 10−2 | 5.94 |
| GO:0046873 | Metal ion transmembrane transporter activity | 2.54 × 10−4 | 6.07 × 10−2 | 2.86 |
| GO:0015318 | Inorganic molecular entity transmembrane transporter activity | 3.00 × 10−4 | 6.77 × 10−2 | 2.22 |
| GO:0015075 | Ion transmembrane transporter activity | 4.10 × 10−4 | 8.77 × 10−2 | 2.13 |
| GO:0005125 | Cytokine activity | 4.24 × 10−4 | 8.61 × 10−2 | 4.44 |
| GO:0022890 | Inorganic cation transmembrane transporter activity | 4.73 × 10−4 | 9.15 × 10−2 | 2.43 |
| GO:0004930 | G-protein–coupled receptor activity | 4.95 × 10−4 | 9.14 × 10−2 | 3.32 |
| GO:0008324 | Cation transmembrane transporter activity | 5.54 × 10−4 | 9.80 × 10−2 | 2.33 |
| GO:0005184 | Neuropeptide hormone activity | 5.76 × 10−4 | 9.76 × 10−2 | 41.59 |
| GO:0005139 | IL-7 receptor binding | 5.76 × 10−4 | 9.37 × 10−2 | 41.59 |
| GO:0003858 | 3-hydroxybutyrate dehydrogenase activity | 5.76 × 10−4 | 9.01 × 10−2 | 41.59 |
| GO:0022857 | Transmembrane transporter activity | 6.53 × 10−4 | 9.83 × 10−2 | 1.96 |
Definition of abbreviations: FDR = false discovery rate; GO = gene ontology.