Table 2.
Wild-Type Chronic Hypoxia versus Chronic Hypoxia HIF-1α KO Right Ventricle
| GO Term | Description | P Value | FDR q Value | Enrichment |
|---|---|---|---|---|
| GO Process (log fold change >1.5) | ||||
| GO:0007186 | G-protein–coupled receptor signaling pathway | 1.13 × 10−4 | 1.00 × 1 | 3.92 |
| GO:1902533 | Positive regulation of intracellular signal transduction | 1.46 × 10−4 | 1.00 × 1 | 2.73 |
| GO:0032642 | Regulation of chemokine production | 1.60 × 10−4 | 7.53 × 10−1 | 9.69 |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | 1.66 × 10−4 | 5.88 × 10−1 | 6 |
| GO:0050917 | Sensory perception of umami taste | 2.42 × 10−4 | 6.84 × 10−1 | 73.66 |
| GO:0021569 | Rhombomere 3 development | 2.42 × 10−4 | 5.70 × 10−1 | 73.66 |
| GO:0035284 | Brain segmentation | 2.42 × 10−4 | 4.89 × 10−1 | 73.66 |
| GO:0042327 | Positive regulation of phosphorylation | 4.10 × 10−4 | 7.24 × 10−1 | 2.5 |
| GO:0051897 | Positive regulation of protein kinase B signaling | 4.21 × 10−4 | 6.61 × 10−1 | 7.89 |
| GO:0006032 | Chitin catabolic process | 4.81 × 10−4 | 6.80 × 10−1 | 55.24 |
| GO:0006030 | Chitin metabolic process | 4.81 × 10−4 | 6.18 × 10−1 | 55.24 |
| GO:0050916 | Sensory perception of sweet taste | 4.81 × 10−4 | 5.67 × 10−1 | 55.24 |
| GO:0032722 | Positive regulation of chemokine production | 4.98 × 10−4 | 5.41 × 10−1 | 10.78 |
| GO:0050906 | Detection of stimulus involved in sensory perception | 5.46 × 10−4 | 5.51 × 10−1 | 10.52 |
| GO:0051896 | Regulation of protein kinase B signaling | 5.81 × 10−4 | 5.47 × 10−1 | 5.82 |
| GO:1904894 | Positive regulation of STAT cascade | 6.53 × 10−4 | 5.77 × 10−1 | 10.04 |
| GO:0001934 | Positive regulation of protein phosphorylation | 6.67 × 10−4 | 5.54 × 10−1 | 2.48 |
| GO:0098870 | Action potential propagation | 7.98 × 10−4 | 6.26 × 10−1 | 44.19 |
| GO:0019227 | Neuronal action potential propagation | 7.98 × 10−4 | 5.93 × 10−1 | 44.19 |
| GO:0021546 | Rhombomere development | 7.98 × 10−4 | 5.64 × 10−1 | 44.19 |
| GO:0010562 | Positive regulation of phosphorus metabolic process | 8.73 × 10−4 | 5.87 × 10−1 | 2.34 |
| GO:0045937 | Positive regulation of phosphate metabolic process | 8.73 × 10−4 | 5.61 × 10−1 | 2.34 |
| GO function (log fold change >1.5) | ||||
| GO:0048018 | Receptor ligand activity | 1.26 × 10−7 | 5.12 × 10−4 | 7.05 |
| GO:0030545 | Receptor regulator activity | 2.89 × 10−7 | 5.90 × 10−4 | 6.53 |
| GO:0008083 | Growth factor activity | 1.14 × 10−5 | 1.55 × 10−2 | 9.1 |
| GO:0038023 | signaling receptor activity | 2.69 × 10−5 | 2.74 × 10−2 | 3.45 |
| GO:0008201 | Heparin binding | 3.76 × 10−5 | 3.06 × 10−2 | 7.58 |
| GO:0004930 | G-protein–coupled receptor activity | 5.78 × 10−5 | 3.93 × 10−2 | 5.97 |
| GO:0005125 | Cytokine activity | 6.28 × 10−5 | 3.66 × 10−2 | 8.72 |
| GO:0060089 | Molecular transducer activity | 8.34 × 10−5 | 4.25 × 10−2 | 3.13 |
| GO:0004888 | Transmembrane signaling receptor activity | 1.22 × 10−4 | 5.53 × 10−2 | 3.6 |
| GO:0005539 | Glycosaminoglycan binding | 1.66 × 10−4 | 6.78 × 10−2 | 6 |
| GO:0071837 | HMG box domain binding | 2.44 × 10−4 | 9.06 × 10−2 | 23.68 |
| GO:0004568 | Chitinase activity | 4.81 × 10−4 | 1.64 × 10−1 | 55.24 |
| GO:0008061 | Chitin binding | 4.81 × 10−4 | 1.51 × 10−1 | 55.24 |
| GO:0016709 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen NAD(P)H as one donor, and incorporation of one atom of oxygen | 7.36 × 10−4 | 2.14 × 10−1 | 16.57 |
| GO:1901681 | Sulfur compound binding | 7.68 × 10−4 | 2.09 × 10−1 | 4.66 |
Definition of abbreviations: HIF-1α = hypoxia-inducible factor-1α; HMG = high mobility group; KO = knockout; NAD(P)H = nicotinamine adenine dinucleotide phosphate (reduced); STAT = signal transducers and activators of transcription.