Table 4.
Wild-Type Chronic Hypoxia versus Chronic Hypoxia HIF-1α/HIF-2α KO Right Ventricle
| GO Term | Description | P Value | FDR q Value | Enrichment |
|---|---|---|---|---|
| GO process (log fold change >1.5) | ||||
| GO:0030595 | Leukocyte chemotaxis | 2.26 × 10−6 | 3.20 × 10−2 | 9.25 |
| GO:0050900 | Leukocyte migration | 6.30 × 10−6 | 4.45 × 10−2 | 6.87 |
| GO:0097529 | Myeloid leukocyte migration | 8.28 × 10−6 | 3.90 × 10−2 | 9.5 |
| GO:0010959 | Regulation of metal ion transport | 2.62 × 10−5 | 9.25 × 10−2 | 3.94 |
| GO:0043269 | Regulation of ion transport | 4.72 × 10−5 | 1.33 × 10−1 | 3.15 |
| GO:0060326 | Cell chemotaxis | 5.24 × 10−5 | 1.23 × 10−1 | 6.05 |
| GO:0030593 | Neutrophil chemotaxis | 7.51 × 10−5 | 1.52 × 10−1 | 11.25 |
| GO:0006952 | Defense response | 1.03 × 10−4 | 1.83 × 10−1 | 2.72 |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | 1.13 × 10−4 | 1.77 × 10−1 | 4.78 |
| GO:0071621 | Granulocyte chemotaxis | 1.23 × 10−4 | 1.73 × 10−1 | 10.18 |
| GO:0070488 | Neutrophil aggregation | 1.36 × 10−4 | 1.74 × 10−1 | 85.52 |
| GO:1990266 | Neutrophil migration | 1.37 × 10−4 | 1.62 × 10−1 | 9.94 |
| GO:0097530 | Granulocyte migration | 2.11 × 10−4 | 2.29 × 10−1 | 9.1 |
| GO:1904062 | Regulation of cation transmembrane transport | 2.14 × 10−4 | 2.16 × 10−1 | 3.98 |
| GO:0060340 | Positive regulation of type I IFN-mediated signaling pathway | 2.41 × 10−4 | 2.27 × 10−1 | 23.32 |
| GO:0006935 | Chemotaxis | 2.51 × 10−4 | 2.22 × 10−1 | 4.3 |
| GO:0042330 | Taxis | 2.72 × 10−4 | 2.26 × 10−1 | 4.25 |
| GO:0051480 | Regulation of cytosolic calcium ion concentration | 2.84 × 10−4 | 2.23 × 10−1 | 4.23 |
| GO:0002684 | Positive regulation of immune system process | 3.13 × 10−4 | 2.33 × 10−1 | 2.58 |
| GO:0002523 | Leukocyte migration involved in inflammatory response | 3.19 × 10−4 | 2.25 × 10−1 | 21.38 |
| GO:0031349 | Positive regulation of defense response | 3.75 × 10−4 | 2.52 × 10−1 | 4.07 |
| GO:0023052 | Signaling | 4.66 × 10−4 | 2.99 × 10−1 | 3.61 |
| GO:0007267 | Cell–cell signaling | 4.71 × 10−4 | 2.89 × 10−1 | 3.95 |
| GO:0048705 | Skeletal system morphogenesis | 5.68 × 10−4 | 3.35 × 10−1 | 5.83 |
| GO:0051049 | Regulation of transport | 5.82 × 10−4 | 3.29 × 10−1 | 1.91 |
| GO:0034765 | Regulation of ion transmembrane transport | 6.32 × 10−4 | 3.44 × 10−1 | 3.22 |
| GO:0007589 | Body fluid secretion | 6.33 × 10−4 | 3.31 × 10−1 | 10.06 |
| GO:0050801 | Ion homeostasis | 6.38 × 10−4 | 3.22 × 10−1 | 2.61 |
| GO:0050878 | Regulation of body fluid levels | 6.78 × 10−4 | 3.31 × 10−1 | 4.17 |
| GO:0051707 | Response to other organism | 6.93 × 10−4 | 3.26 × 10−1 | 2.99 |
| GO:0032101 | Regulation of response to external stimulus | 6.93 × 10−4 | 3.16 × 10−1 | 2.59 |
| GO:0018119 | Peptidyl-cysteine S-nitrosylation | 8.02 × 10−4 | 3.54 × 10−1 | 42.76 |
| GO:0051459 | Regulation of corticotropin secretion | 8.02 × 10−4 | 3.44 × 10−1 | 42.76 |
| GO:0051461 | Positive regulation of corticotropin secretion | 8.02 × 10−4 | 3.34 × 10−1 | 42.76 |
| GO:0010524 | Positive regulation of calcium ion transport into cytosol | 8.78 × 10−4 | 3.54 × 10−1 | 9.25 |
| GO:0140013 | Meiotic nuclear division | 8.78 × 10−4 | 3.45 × 10−1 | 9.25 |
| GO:0060338 | Regulation of type I IFN-mediated signaling pathway | 9.44 × 10−4 | 3.61 × 10−1 | 15.09 |
| GO:0050678 | Regulation of epithelial cell proliferation | 9.53 × 10−4 | 3.55 × 10−1 | 3.29 |
| GO:0006874 | Cellular calcium ion homeostasis | 9.82 × 10−4 | 3.56 × 10−1 | 3.28 |
| GO:0051924 | Regulation of calcium ion transport | 9.98 × 10−4 | 3.53 × 10−1 | 3.93 |
| GO function (log fold change >1.5) | ||||
| GO:0005509 | Calcium ion binding | 4.36 × 10−6 | 1.78 × 10−2 | 3.82 |
| GO:0035662 | Toll-like receptor 4 binding | 4.04 × 10−4 | 8.24 × 10−1 | 57.01 |