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. Author manuscript; available in PMC: 2021 Sep 11.
Published in final edited form as: Can J Physiol Pharmacol. 2020 Sep 11;98(9):579–586. doi: 10.1139/cjpp-2019-0688

Figure 2: Female Global PER1 KO Mice have Increased ET-1 during Active Period Following HS+DOCP.

Figure 2:

Na excretion was measure in WT and female global PER1 KO mice 12-hr collections under a normal salt diet (NS), high salt diet (HS), and HS+DOCP treatment (A). Night (N) corresponds to 6pm-6am (lights off; mouse active period). Day (D) corresponds to 6am-6pm (lights on; mouse inactive period). Night/day ratio of Na excretion (B) and food intake (C) on the HS/DOCP treatment was calculated as previously done for male mice (REF DOUMA 2018). 12-Hour urinary ET-1 peptide in female WT and global PER1 KO mice immediately following a HS/DOCP treatment (D). Night/Day ratio of urinary ET-1 excretion was calculated for the 1st 24-hrs on the HS/DOCP treatment (E) and for 72hrs on the treatment (F). N=6 per group, statistical significance measured by T-test WT vs. KO (*P<0.05).