Table 3.

Multivariable Analysis for the Prediction of Mortality: Patients with Baseline Renin Above Study Median Only

	Hazard Ratio (95% CI)	P Value
Model A
Treatment arm, angiotensin II	0.58 (0.36–0.93)	0.02
Baseline APACHE II score > 30	2.02 (1.29–3.18)	0.002*
Baseline MAP < 65 mm Hg	1.76 (1.12–2.77)	0.01
Model B
Treatment arm, angiotensin II	0.62 (0.38–0.99)	0.04
Baseline NED ≥ 0.5 μg/kg/min	1.88 (1.19–2.98)	0.007*
Baseline MELD ≥ 30	1.43 (0.81–2.50)	0.21
Model C
Treatment arm, angiotensin II	0.62 (0.39–0.98)	0.04
Baseline APACHE II score > 30	2.03 (1.29–3.19)	0.002*
Baseline MAP < 65 mm Hg	1.66 (1.06–2.62)	0.03
Baseline NED ≥ 0.5 μg/kg/min	1.78 (1.13–2.83)	0.01

Definition of abbreviations: APACHE II = Acute Physiology and Chronic Health Evaluation II; CI = confidence interval; MAP = mean arterial pressure; MELD = Model for End-Stage Liver Disease; NED = norepinephrine equivalent dose.

Model A includes treatment assignment and stratification variables. Model B includes covariates that were imbalanced by P < 0.10 in the population clinical characteristics. Model C includes the statistically significant variables from model A and model B.

^*P < 0.01.