Figure 4.

Risk assessment flow diagram for [TIMP-2] · [IGFBP7] (the product of tissue inhibitor of metalloproteinases-2 and insulin-like growth factor–binding protein 7) at (A) Hour 0 and at (B) Hour 6 in combination with serum creatinine and urine output in predicting the risk of the primary endpoint. The red boxes indicate the positivity of the criteria (when serum creatinine and urine output meet Kidney Disease: Improving Global Outcomes criteria for acute kidney injury (AKI) stage 1, or when [TIMP-2] · [IGFBP7] values are greater than the cutoff). The green boxes represent the condition of normal serum creatinine, urine output (no clinical AKI), and biomarker negativity. For each combination, we reported the proportion of patients who achieved the primary endpoint.